王晓东　（Xiaodong Wang, Ph.D.） Professor of Biochemistry Assistant Investigator, Howard Hughes Medical Institute ，美国科学院院士

1980－1984年就读于北京师范大学生物系本科，1984年赴美留学，主要致力于研究哺乳动物细胞凋亡的路径及其生化调控机制。

主要著作： Xu Luo, Imawati Budihardjo, Hua Zou, Clive Slaughter, and Xiaodong Wang (1998). Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors. Cell, 94: 481-490.

Peng Li, Deepak Nijhawan, Ima Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemri & Xiaodong Wang (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489

Hua Zou,Willaim J. Henzel, Xuesong Liu, Alexis Lutschg, and Xiaodong Wang (1997). Apaf-1, a human protein homologous to C. elegans CED-4 participates in Cytochrome c-dependent activation of Caspase-3. Cell,90 (3):405-413.

Xuesong Liu, Hua Zou, Clive Slaughter, Xiaodong Wang (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.Cell, 89 (2): 175-184.

Jie Yang, Liu Xuesong, Kapil Bhalla, Caryn Naekyung Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones, Xiaodong Wang (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275(5303): 1129-1132.

Xuesong Liu, Caryn Naekyung Kim, Jie Yang, Ronald Jemmerson, and Xiaodong Wang (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86, 147-157.

Du,C.Y., Fang,M., Li,Y.C., Li,L., Wang,X.D. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102(1) (2000) Jul 7

Li,K., Li,Y.C., Shelton,J.M., Richardson,J.A., Spencer, E., Chen,Z.J., Wang,X.D., Williams,R.S. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell, 101(4) (2000) May 12

Luo,X., Budihardjo,I., Zou,H., Slaughter,C., Wang,X.D. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94(4) (1998) Aug 21

Li,P., Nijhawan,D., Budihardjo,I., Srinivasula,S.M.,Ahmad,M., Alnemri,E.S., Wang,X.D. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91(4) (1997) Nov 14

Parrish,J., Li,L.L., Klotz,K., Ledwich,D., Wang,X.D., Xue,D. Mitochondrial endonuclease G is important for apoptosis in C-elegans. Nature, 412(6842) (2001) Jul 5

Li,L.Y., Luo,L., Wang,X.D. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature, 412(6842) (2001) Jul 5 Wu,G., Chai,J.J., Suber,T.L., Wu,J.W., Du,C.Y., Wang,X.D., Shi,Y.G. Structural basis of IAP recognition by Smac/DIABLO. Nature, 408(6815) (2000) Dec 21

Chai,J.J., Du,C.Y., Wu,J.W., Kyin,S., Wang,X.D., Shi,Y.G. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature, 406(6798) (2000) Aug 24

Xuesong Liu, Peng Li, Widlak P, Hua Zou,Xu Luo,William T Garrard,Xiaodong Wang (1998) The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A 95(15):8461-6.

Xuesong Liu, Caryn Naekyung Kim, Jan Pohl and Xiaodong Wang (1996). Purification and characterization of an interleukin-1b-converting enzyme family protease that activates cysteine protease P32 (CPP32). J.Biol. Chem. 271, 13371-13376.