副教授 / 高级工程师 / 高级实验师
教师简历
微信图片_20230217161157.jpg      
张博文        
博士  副教授             
   

Email: zhangbw@bnu.edu.cn
个人主页:
http://cmb.bnu.edu.cn/teachers/zhangbw.htm
https://www.researchgate.net/profile/Bowen-Zhang-26

个人简历

2014年获北京师范大学生物科学理学学士学位,2019年获北京师范大学生态学理学博士学位,2019年-2022年在德国亥姆霍兹联合会感染研究中心(HZI)进行博士后进修。2022年至今在北京师范大学生态学研究所工作。承担《生物统计学》、《组学数据分析》等课程的教学。以第一作者或共同第一作者在Cell, Cell Genomics, Current Biology, Molecular Biology & Evolution等国际知名学术期刊发表研究论文多篇。担任Journal of Systematics and Evolution青年编委等社会工作。


研究背景

主要致力于在群体基因组的背景下,利用生物信息学和系统生物学的方法,探究基因组的演化在生物多样性的起源和维持中的作用,挖掘生物大数据背后的生物学意义。近年来重点开展了以胡桃科为研究对象的物种形成、基因流与种群动态研究,以及利用单细胞转录组和泛基因组对其关键性状进行分子表型和遗传调控研究。


代表性研究成果

研究论文

1.  Liu, ZZ, Xu, Q, Han, YQ, Song, YF., Liu, HS, Zhang, DY*, Bai, WN* and Zhang, BW* (2026), WalDB: An evolutionary multi-omics database for the walnut family (Juglandaceae). Journal of Systematics and Evolution: jse.70095.

2.  Liu, HS; Wang, WH; Song, YF; Yang, Y; Zhang, DY*; Bai, WN*; Zhang, BW* (2025) A pan-genome framework reveals structural variation and small RNA regulation underlying heterodichogamy in Pterocarya, Current Biology, 35(21): 5179-5191.

3.  Wang, WH; Renner, SS; Liu, HS; Dai, LF; Chen, CJ; Zhang, Y; Zhang, BW*; Zhang, DY*; & Bai, WN*. (2025). Genetic Mechanisms and Adaptive Benefits of Anthocyanin Red Stigmas in a Wind-Pollinated Tree. Molecular biology and evolution, 42(3), msaf040.

4.  Cao, Y; Almeida-Silva, F; Zhang, WP; Ding, YM; Bai, D; Bai, WN*; Zhang, BW*; Van de Peer, Y.*; Zhang DY*. (2023) Genomic Insights into Adaptation to Karst Limestone and Incipient Speciation in East Asian Platycarya spp. (Juglandaceae), Molecular Biology and Evolution, 40(6): 1-17

5.  Zhang, B.#; Zhang, Z.#; Koeken, V.#; Kumar, S.; Aillaud, M.; et al. (2022)Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19, Cell Genomics, 100232: online.

6.  Zhang, B.#; Moorlag, S.#; Dominguez-Andres, J.; Bulut, O.; Kilic, G.; Liu, Z.; et al.(2022)Single-cell RNA sequencing reveals induction of distinct trained immunity programs in human monocytes, Journal of Clinical Investigation,132(e147719): 1-17.

7.  Zhang, B.#; Roesner, L.#; Traidl, S.#; Koeken, V.; Xu, C-J.; Werfel, T.; Li, Y. (2022)Single-cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis, Allergy, 00: 1-15.

8.  Schulte-Schrepping, J.#; Reusch, N.#; Paclik, D.#; Baßler, K.#; Schlickeiser, S.#; Zhang, B.#; et al. (2020)Severe COVID-19 is marked by a dysregulated myeloid cell compartment, Cell, 182(6): 1419-1440.

9.  Zhang, B.#; Xu, L#; Li, N#; Yan, P; Jiang, X; Woeste, K.; Lin, K; et al.(2019) Phylogenomics Reveals an Ancient Hybrid Origin of the Persian Walnut, Molecular Biology and Evolution, 36(11): 2451-2461

(#共同第一作者, *共同通讯作者)









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