以模式生物果蝇为研究模板，利用遗传学、细胞学、分子生物学、生物信息学等实验技术与方法，深入探究不平衡基因组内基因剂量效应的分子机制，果蝇雌雄个体间剂量补偿现象的分子机理以及表观遗传学在不平衡基因组内的调控机制。

科研项目

主持在研国家自然科学基金面上项目：非整倍体中RNAm6A甲基化的分子调控机制，32070566, 2021.01-2024.12

主持结题国家自然科学基金面上项目：MSL复合体对反式剂量效应的调控机制，31871243,2019.01-2022.12.

主持结题北京师范大学自主科研学科交叉重大项目:非整倍体果蝇反式剂量效应性别差异反应的分子机制研究, 2015KJJCA10, 2015.06-2018.05.

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2. ZHang, S., Wang, R; Zhu X., Zhang,L; Liu,X; Sun, L.Characteristics and expression of lncRNA andtransposable elements in Drosophila aneuploidy. iScience, 2023,26(12),108494

3. Liu X, Yan R, Liu H, Zhang S, Wang R, Zhang B, Sun L. Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in Metafemale Drosophila. Int J Mol Sci. 2023 May 6;24(9):8381.

4. Zhang, L., Zhang, S., Wang, R., Sun, L. Genome-Wide Identification of Long Noncoding RNA and Their Potential Interactors in ISWI Mutants. Int. J. Mol. Sci, 2022, 23, 6247.

5. 张帅,孙林.非整倍体中的反式调控机制[J].中国科学:生命科学,2022,52(08):1192-1202.

6. Zhang Shuai, Qi Haizhu, Huang Cheng, Yuan Lijia, Zhang Ludan, Wang Ruixue, Tian Yu, Sun Lin. (2021) Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila. Scientific Reports,11(1):19679.

7. Zhang Shuai, Wang Ruixue, Huang Cheng, Zhang Ludan, Sun Lin. (2021) Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes. Genes, 12 (10):1606.

8. Lian He, Liuqing Wang,... Lin Sun, Youjun Wang& Yubin Zhou ,et al. Engineering of a bona fide light-operated calcium channel[J]. NATURE COMMUNICATIONS, 2021,12:164.

9. Jilong Li, Jia Hou, Lin Sun and et al., (2015) From Gigabyte to Kilobyte: A Bioinformatics Protocol for Mining Large RNA-Seq Transcriptomics Data. Plos One. 10(4):e0125000.

10. Sun L, Johnson AF, Li J, Lambdin AS, Cheng J & Birchler JA (2013) Differential effect of aneuploidy on the X chromosome and genes with sex-biased expression in Drosophila. Proc. Natl. Acad. Sci. USA110(41):16514-16519.

11. Sun L, Johnson AF, Donohue RC, Li J, Cheng J & Birchler JA (2013) Dosage compensation and inverse effects in triple X metafemales of Drosophila. Proc. Natl. Acad. Sci. USA 110(18):7383-8.

12. Sun L, Fernandez HR, Dohohue RC, Li J, Cheng J & Birchler JA (2012) Male specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation. Proc. Natl. Acad. Sci. USA 110(9):E808-17.