教授、博士生导师
办公室：科技楼B815电话：15210659470
E-mail：chensr@bnu.edu.cn
学术主页：https://www.researchgate.net/profile/Su_Ren_Chen
https://orcid.org/0000-0002-9337-5412
内蒙古呼伦贝尔市人。2009年保送进入中国科学院动物研究所（干细胞与生殖生物学国家重点实验室）硕博连读，导师为我国著名生殖生物学家刘以训院士，2014年博士毕业后留所先后任助理研究员和副研究员。2019年入职北京师范大学生命科学学院，任副教授、博士生导师、课题组长，研究方向为精子生物学和男性不育遗传学，2024年晋升教授。学术成果以通讯作者（含共同）发表在Protein Cell, Human Reproduction Update, Science Advances, eBioMedicine, Cell Reports, eLife, Human Reproduction和Development等国际主流学术期刊上。曾入选第二届中国科协“青年人才托举工程”，获第五届全国妇幼健康科学技术奖自然科学二等奖（第一完成人）和北京师范大学优秀博士学位论文指导教师等荣誉，受聘为全国研究生教育评估监测专家库专家和多项基金评审专家。讲授本科生《遗传学实验》、《生殖的奥秘—生殖生物学与医学》、《带你了解遗传病—医学遗传学》和研究生《生殖生物学与医学》等课程，获北京师范大学课程思政建设优秀课程和优秀新生导师等荣誉，所指导的研究生多人次获国家奖学金和北京市优秀毕业生。
精子生物学：利用多种基因编辑动物模型研究精子变形过程；与合作者解析精子结构的高分辨率原位结构；将原位结构生物学与基因编辑动物模型相结合，揭示精子运动缺陷背后的结构基础。
男性不育遗传学：利用临床男性不育患者样本开展全外显子测序，发掘致病基因变异；应用电镜等高分辨率成像技术研究精子结构缺陷；构建疾病相关动物模型深入揭示发病机理。
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1. Wang J#, Jin HJ#, Lu Y, Wang ZH, Li TY, Xia L, Li HJ*, Wang BB*, Chen SR*. (2024) Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome. Protein Cell. pwae018.
2. Jin HJ#, Fan Y#, Yang XY#, Dong Y, Zhang XZ, Geng XY, Yan Z, Wu L, Ma M, Li B, Lyu Q, Pan Y, Liu MX*, Kuang YP*, Chen SR*. (2024) Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. eLife. 13:RP95054.
3. Zhang Q#, Jin HJ#, Long SH, Tang XR, Li JX, Liu WW, Han W, Liao HY, Fu T, Huang GN*, Chen SR*, Lin TT*. (2024) Deletion of ACTRT1 is associated with male infertility as sperm acrosomal ultrastructural defects and fertilization failure in human. Human Reproduction. 39(5):880-891.
4. Geng XY, Jin HJ, Xia L, Wang BB*, Chen SR*. (2024) Tektin bundle interacting protein, TEKTIP1, functions to stabilize the tektin bundle and axoneme in mouse sperm flagella. Cellular and Molecular Life Sciences. 81(1):118.
5. Jin HJ#, Wang JL#, Geng XY, Wang CY, Wang BB*, Chen SR*. (2023) CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men. eBioMedicine. 93:104675.
6. Jin HJ#, Ruan TC#, Dai SY#, Geng XY, Yang YH*, Shen Y*, Chen SR*. (2023) Identification of CFAP52 as a novel diagnostic target of male infertility with defects of sperm head-tail connection and flagella development. eLife. 12:RP92769.
7. Zhang XZ, Wei LL, Jin HJ, Zhang XH, Chen SR. (2022) The perinuclear theca protein Calicin helps shape the sperm head and maintain the nuclear structure in mice. Cell Reports. 40(1):111049.
8. Zhang XG#, Zheng R#, Liang C#, Liu HT#, Zhang XZ#, Ma YY, Liu MH, Zhang W, Yang Y, Liu M, Jiang C, Ren QJ, Wang Y*, Chen SR*, Yang YH*, Shen Y*. (2022) Loss-of-function mutations in CEP78 cause male infertility in humans and mice. Science Advances. 8, eabn0968.
9. Zhang XZ#, Wei LL#, Zhang XH, Jin HJ, Chen SR. (2022) Loss of perinuclear theca ACTRT1 causes acrosome detachment and severe male subfertility in mice. Development. 149(12):dev200489.
10. Jiao SY, Yang YY*, Chen SR*. (2021) Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice. Human Reproduction Update. 27(1):154-189.
（#共同第一作者，*共同通讯作者）
