【报告人】：陈刚  教授

【报告人简介】：

陈刚，南京中医药大学博导，江苏省特聘教授，江苏双创团队领军人才，江苏双创人才，中医脑病重点实验室主任。美国罗格斯大学心理学博士，曾在OHSU，密歇根大学等从事神经精神疾病前沿研究。北京师范大学生物系97届生理学硕士，2012年回国后，发掘传统复方越鞠丸在抑郁症痴呆症中医药个性化治疗中的优势特征，开展其现代科学本质与新机制等研发工作，在国际上发表论文20余篇，十多次在海外学术会议上主持或报告。国际行为与神经遗传学会执行委员，“科学中国人”2015年度人物。

【报告内容摘要】：

Yueju pill is a Traditional Chinese Medicine (TCM) which consists of five herbs,formulated to treat depression-related syndromes at 800 years ago. Conventional antidepressants have a major disadvantage in delayed onset for depression treatment. Recently, we found that Yueju promotes fast-onset antidepressant-like efficacy in clinical and preclinical studies. A single dose of Yueju rapidly attenuates the depression-like symptoms in various animal models and the antidepressant effects could last even longer than ketamine, the prototype fast- acting antidepressant with adverse behavioral and neurotoxic potential. We also revealed the critical neuromolecular mechanisms involving improved neural plasticity by Yueju. Moreover, Yueju targeted more therapeutic sites, and the activation of PKA-CREB-BDNF signaling pathway or not underlies the strain- dependent differences in the lasting antidepressant effects. Yueju was also effective in a novel model of treatment-resistant postpartum depression. Importantly, a clinical pilot study supported its fast-onset antidepressant efficacy.